Natalia attributes her rigorous work ethic, discipline and instrumental predisposition to her parents. The daughter of violinist/conductor Pinchas Zukerman and flutist/writer Eugenia Zukerman, Natalia grew up in Manhattan immersed in classical music. Her ears were tuned to perfect pitch, and the guitar dexterity, intricate sense of rhythm and meter evident in her own musicianship came naturally. So did the lifestyle of a traveling performer. Performing live—and experiencing what she calls the life of a “wandering gypsy”—is a family tradition. In addition to her parents, her sister Arianna is an opera singer, and her grandfather played clarinet in Klezmer bands in Poland and later in Israel.

Natalia's musical life is in part about blood-related family but even more so about the extended family of American troubadours who travel the country sharing both traditional and contemporary genres, songs, skills, instruments, and styles. Since 2004, Zukerman has been touring the country opening shows for roots greats and guitar slingers including Kelly Joe Phelps, Richard Shindell, Lucy Kaplansky, Garnet Rogers, Melissa Ferrick, Catie Curtis, Susan Werner and many others.